There are many recipes for papaya smoothies on the Web, but most call for the seeds to be removed and discarded. Papaya seeds are edible and add an interesting spicy flavour if used in the smoothie.
I made mine by putting the flesh and seeds of one papaya in the tumbler and topping up with white grape juice to the level of the fruit. Vigorous blending crushed the seeds in this mixture and I passed the smoothie through a fine mesh sieve to get the black seed bits out. It did not take long, or too much elbow grease to do this, but the result was excellent and unusual.